CA-310

Karl-Fischer moisture measurement system for the highest requirements and maximum flexibility

✓ Integrated CFR21 Part 11 data integrity

✓ for solids, liquids, gases, LPGs, etc.

✓ coulometric and volumetric Karl Fischer titration

✓ Scalability to up to 4 active titration channels

✓ Determination of the bromine index

Your advantages

Data integrity: supports the requirements of GMP (Good Manufacturing Practice), GLP (Good Laboratory Practice) and CFR21 Part 11

Conformity: to almost all relevant standard procedures of the Karl Fischer determination

Large measuring range: thanks to coulometric and volumetric measuring cell

Measurement of residual moisture: in organic and inorganic solids, liquids, gases, liquid gases and viscous samples

Over 25 years of experience: the manufacturer Nittoseiko (formerly Mitsubishi) has been a leader in Karl Fischer titration for over 25 years

Maximum flexibility: thanks to modular system with up to 4 active titration channels

Resource protection

Designed for longevity: robust workmanship, clear & simple handling, service and spare parts. One example is the TOX-100 analyzer, which we sold from 1997 to 2013. Around 80% of these analyzers are still in use today – and are repaired, serviced and supplied with spare parts.

Sustainability: Compatibility with Karl Fischer sample introduction systems, reagent changers, burettes and additional measuring channels

Cost efficiency: offers options for high-throughput automation

Easy handling

Integrated control unit: controllable without a separate PC and software

Connectivity: enables the network export of data to a LIMS (Laboratory Information and Management System)

Wireless connection between controller and titration cell: enables use in glove and safety boxes or enclosures

User-friendliness: thanks to touchscreen

Possible samples: organic and inorganic solids, liquids, gases, liquid gases and viscous samples

A wide range of applications: for example in the pharmaceutical industry, petrochemicals, energy, chemicals, food, food supplements, agriculture and wherever moisture occurs

Our service for you

Comprehensive training: we take over the induction of your employees

Also there for you after the purchase: many questions only arise during work. We are here to answer all your questions about the device and your measurement

Full compatibility: with all Nittoseiko vaporizers

Unique: Measuring devices and Karl Fischer reagents from a single source

Application

Applications

The Ca-310 is used to measure the residual moisture in organic and inorganic solids, liquids, gases, liquid gases and viscous samples.

Some sample examples are:

Organic compounds:

  • Hydrocarbons
  • Halogenated hydrocarbons
  • Alcohols
  • Ether
  • Phenols
  • Ketones
  • Aldehydes
  • organic acids
  • Ester
  • organic acid salts
  • organic hydrates
  • Amines
  • Amide
  • Anilide
  • Nitrile
  • Cyanohydrine
  • Hydrazine
  • Acid anhydrides
  • Acid chlorides
  • Quinone
  • Peroxides
  • Sulphur compounds

Inorganic compounds:

  • Metals and simple substances
  • inorganic acids
  • Hydroxides
  • Oxides
  • Halides
  • Carbonates
  • Bicarbonates
  • Sulfates
  • Sulfites
  • inorganic gases

Industrial products:

  • Fertilizer
  • Agricultural chemicals
  • Glass/ceramic
  • Liquid gases
  • Coals
  • Tars
  • Petroleum products
  • Plastics
  • Rubber
  • Rubber products
  • Additives
  • fibers
  • Papers
  • Dye intermediates
  • Pigments
  • Colors
  • Printing inks and image materials
  • Adhesives
  • Soaps and detergents
  • Cosmetics
  • Chemicals and materials for electronic
  • Appliances and electrical parts

Food:

  • Food additives and flavorings
  • Cereals and dried vegetables
  • Sugar and spices
  • Confectionery
  • Dairy products
  • Fat products
  • Gourmet food

Pharmaceutical products:

  • Biochemical products
  • Pharmaceuticals
  • Chinese herbal medicine
  • biological tissue

Minerals and natural products:

  • Minerals
  • Natural products

Control of the CA-310

The CA-310 is equipped with its own control unit, so no additional PC or software is required. It is simply operated via a touchscreen. The wireless connection between the controller and the Karl Fischer titration cell allows the device to be used in a glove or safety box or enclosure.

Data integrity

The CA-310 supports GMP (Good Manufacturing Practice)/GLP (Good Laboratory Practice) and FDA 21 CFR requirements for data integrity and offers the option of exporting data via a network to a LIMS (Laboratory Information and Management System) and displaying it graphically.

Scalability

The CA-310 is a modular system and allows scalability to up to 4 active titration channels. It offers increased flexibility with the ability to switch between coulometric and volumetric measurement. The device is fully compatible with all Nittoseiko evaporators and offers options for high throughput automation.

Standard methods

The modularity of the CA-310 conforms to almost all relevant standard procedures of the Karl Fischer determination.

These are among others:

ASTMD890, ASTMD1159, ASTMD1364, ASTMD1533, ASTMD2710, ASTMD3401, ASTMD4017, ASTMD4377, ASTMD5460, ASTMD5530, ASTMD6304, ASTMD6869, ASTMD7375 ASTME1064 ASTME203

ISO 760, ISO 3699, ISO 3839, ISO 4317, ISO 5381, ISO 5536, ISO 6296, ISO 6488, ISO 7105, ISO 7335, ISO 8534, ISO 10101, ISO 10336, ISO 10337, ISO 10362, ISO 11021, ISO 12779, ISO 12937, ISO 14897, ISO 15512, ISO 20764, ISO 20938

IEC 60814

Measuring method

What procedures does the CA-310 use?

With the CA-310 you can carry out both coulometric and volumetric Karl Fischer moisture determination. Further information on the procedure can be found on the “Karl Fischer titration” knowledge page

For whom are the measurement results important?

For all companies that want to determine the moisture content of their products or raw materials. These include the pharmaceutical industry, petrochemicals, energy, chemicals, food, food supplements and the agricultural sector

Specifications
Coulometric measuring cell:

  • Measuring range: 10 µg to 100 mg
  • Sensitivity: 0.1 µg H2O

Volumetric measuring cell:

  • Measuring range 0.1 – 999 mg H2O
  • Single or double burette with 10 or 25 ml syringe
  • Burette accuracy: +/- 0.01 ml

Parameters

  • Coulometric Karl Fischer moisture analysis
  • Volumetric Karl Fischer moisture analysis
  • Bromine index

Key data

  • Simultaneous operation of up to 4 channels in any combination of coulometric or volumetric measuring cells
  • Integrated 21 CFR Part 11 Data Integrity
  • Automatic export of data via a network to the LIMS
  • Wireless connectivity between controller and Karl Fischer cell
  • Operation without PC : 8.4-inch color touchscreen
  • Lower measuring limit of 5 µg H2O
  • Reagents and standards tailored to the device
  • Automatic reagent changing system
  • Suitable for measuring bromine number and bromine index
  • Samplers for solids, liquids, gases, LPGs, etc. in the form of autosamplers and vaporizers

FAQ

The CA-310 determines the coulometric Karl Fischer humidity, the volumetric Karl Fischer humidity and the bromine index.

For all companies that want to determine the moisture content of their products or manufacturing materials. These include the pharmaceutical industry, petrochemicals, energy, chemicals, food, food supplements and the agricultural sector.

The CA-310 is used to measure the residual moisture in organic and inorganic solids, liquids, gases, liquid gases and viscous samples.

These are some example samples:

Organic compounds:

  • Hydrocarbons
  • Halogenated hydrocarbons
  • Alcohols
  • Ether
  • Phenols
  • Ketones
  • Aldehydes
  • organic acids
  • Ester
  • organic acid salts
  • organic hydrates
  • Amines
  • Amide
  • Anilide
  • Nitrile
  • Cyanohydrine
  • Hydrazine
  • Acid anhydrides
  • Acid chlorides
  • Quinone
  • Peroxides
  • Sulphur compounds

Inorganic compounds:

  • Metals and simple substances
  • inorganic acids
  • Hydroxides
  • Oxides
  • Halides
  • Carbonates
  • Bicarbonates
  • Sulfates
  • Sulfites
  • inorganic gases

Industrial products:

  • Fertilizer
  • Agricultural chemicals
  • Glass/ceramic
  • Liquid gases
  • Coals
  • Tars
  • Petroleum products
  • Plastics
  • Rubber
  • Rubber products
  • Additives
  • fibers
  • Papers
  • Dye intermediates
  • Pigments
  • Colors
  • Printing inks and image materials
  • Adhesives
  • Soaps and detergents
  • Cosmetics
  • Chemicals and materials for electronic
  • Appliances and electrical parts

Food:

  • Food additives and flavorings
  • Cereals and dried vegetables
  • Sugar and spices
  • Confectionery
  • Dairy products
  • Fat products
  • Gourmet food

Pharmaceutical products:

  • Biochemical products
  • Pharmaceuticals
  • Chinese herbal medicine
  • biological tissue

Minerals and natural products:

  • Minerals
  • Natural products

The CA-310 is equipped with its own control unit, so no additional PC or software is required. It is simply operated via a touchscreen. The wireless connection between the controller and the Karl Fischer titration cell allows the device to be used in a glove or safety box or enclosure.

With the CA-310 you can carry out both coulometric and volumetric Karl Fischer moisture determination. Further information on the procedure can be found on the Karl Fischer titration knowledge page

Yes, the CA-310 supports GMP (Good Manufacturing Practice)/GLP (Good Laboratory Practice) and FDA 21 CFR data integrity requirements and provides the ability to export and graph data over a network to a LIMS (Laboratory Information and Management System).

GMP stands for Good Manufacturing Practice, GLP stands for Good Laboratory Practice. Both are quality assurance regulations for the manufacture of medicinal products.

The Ca-310 is used to measure the residual moisture in organic and inorganic solids, liquids, gases, liquid gases and viscous samples.

There are 2 different Karl Fischer methods. Find out more about the two methods on our Karl Fischer knowledge page.

The measuring range of the coulometric measuring cell is 10 µg to 100 mg.

The measuring range of the volumetric measuring cell is 0.1 – 999 mg H2O.

The sensitivity of the coulometric measuring cell is 0.1 µg H2O.

The burette accuracy of the volumetric measuring cell is +/- 0.01 ml.

Yes, the CA-310 is suitable for measuring the bromine number and bromine index.

No, the CA-310 has its own control unit with touchscreen.

Once your CA-310 has been installed, our service team will be available to provide you with detailed product training. Most questions will arise as you work, so we will also be able to help you with any questions that arise at a later date – at your premises or flexibly via an online meeting.

The modularity of the CA-310 conforms to almost all relevant standard procedures of the Karl Fischer determination.

These are among others:

ASTMD890, ASTMD1159, ASTMD1364, ASTMD1533, ASTMD2710, ASTMD3401, ASTMD4017, ASTMD4377, ASTMD5460, ASTMD5530, ASTMD6304, ASTMD6869, ASTMD7375 ASTME1064 ASTME203

ISO 760, ISO 3699, ISO 3839, ISO 4317, ISO 5381, ISO 5536, ISO 6296, ISO 6488, ISO 7105, ISO 7335, ISO 8534, ISO 10101, ISO 10336, ISO 10337, ISO 10362, ISO 11021, ISO 12779, ISO 12937, ISO 14897, ISO 15512, ISO 20764, ISO 20938

IEC 60814

Accessoires

Optional:

Consumables:

Advice and contact

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Consulting process

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Use our contact form for a non-binding consultation or call us directly. We look forward to your inquiry!

Termine 2025

10. September 2025: Lab Supply Chemnitz
23. – 25. September 2025: Powtech Technopharm Nürnberg
24. September 2025: Lab Supply Leverkusen
8. Oktober 2025: Lab Supply Hamburg
12. November 2025: Lab Supply Augsburg

Dates 2025

September 10, 2025: Lab Supply Chemnitz
September 23 – 25, 2025: Powtech Technopharm Nuremberg
24. September 2025: Lab Supply Leverkusen
8. October 2025: Lab Supply Hamburg
12. November 2025: Lab Supply Augsburg